ABATEMENT OF POTENT P2Y12 ANTAGONIST-BASED DUAL ANTIPLATELET THERAPY AFTER CORONARY INTERVENTION: A NETWORK META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

IntroductionDual antiplatelet therapy (DAPT) including prasugrel or ticagrelor is recommended in patients with acute coronary syndromes (ACS) treated with coronary intervention (PCI).Acknowledging the importance of bleeding, multiple trials tested abatement schemes including uniform or guided de-escalation from the potent P2Y12 inhibitor (P2Y12-De)

Fixed-radius near neighbor search is a fundamental data operation that retrieves all data points within a user-specified distance to a query point.There are efficient algorithms that can provide fast approximate query responses, but they often have a very compute-intensive indexing phase and require careful parameter tuning.Therefore, exact brute f

Recognition (remembrance) as mechanism in identifying the meaning of the liturgical elements in a worship service.It is indicated in research within the field of liturgical studies that participants, during worship services and while participating in all the liturgical elements, have to contend with the process of recognition.The author is conducti

Abstract Background The HIV-1 p6 Gag protein regulates the final abscission step of nascent virions from the cell membrane by the action of two late assembly (L-) domains.Although p6 is located within one of the most polymorphic regions of the HIV-1 gag gene, the 52 amino acid peptide binds at least to two cellular budding factors (Tsg101 and ALIX)